Two sample MR report
ZNF880_Alveolar Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | -0.4605946 | 0.3945317 | 0.3633834 |
| Weighted median | 4 | 0.0436457 | 0.0260068 | 0.0932996 |
| Inverse variance weighted | 4 | 0.0473435 | 0.0225000 | 0.0353651 |
| Simple mode | 4 | 0.0405230 | 0.0389536 | 0.3746760 |
| Weighted mode | 4 | 0.0401451 | 0.0353273 | 0.3383610 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0983013 | 2 | 0.9520377 |
| Inverse variance weighted | 1.7612257 | 3 | 0.6234088 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.3692897 | 0.2863722 | 0.3262135 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 5.56e-05 | 0 | TRUE | 0.4796786 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
